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Piedrahita JA, Oetama B, Bennett GD, van Waes J, Kamen BA, Richardson J et al (1999) Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development

However, with a larger voxel comes difficulties in voxel composition, a 2 cm 3 voxel makes it incredibly difficult to get a pure white matter location and virtually impossible to obtain a pure grey matter placement (104)