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When the body produces and accumulates an excess of free radicals, the balance between free radicals and antioxidants is disrupted

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( Reference Vunta, Davis and Palempalli 44 , Reference Vunta, Belda and Arner 45 ) reported an association between increased pro-inflammatory NF-B activation, increased TNF production and decreased GPx1 activity when macrophages were cultured in Se-deficient media that contained only 6 pmol/ml of Se when compared with cells cultures with 2 nmol/ml of Se ( Reference Vunta, Davis and Palempalli 44 , Reference Vunta, Belda and Arner 45 )

While average plasma glutathione levels were slightly higher with SAG, erythrocyte glutathione levels were somewhat lower compared to regular glutathione (Cavallaro et al., Int J Clin Nutr Diet, 2018) [17]