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& Kimura, G

There is no human clinical trial establishing any effective or safe human dose, oral or injected

10.1038/s41598-022-19634-2 120 RusR

While some mechanisms by which anticancer drugs induce hypertension have been identified, further preclinical and clinical studies are needed to elucidate the exact pathophysiology of hypertension associated with anticancer therapy and to optimize its management [37]