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GHK-Cu works through copper delivery to metalloenzymes and broad gene expression modulation, affecting not only collagen synthesis but also collagen cross-linking (via lysyl oxidase), glycosaminoglycan production, anti-inflammatory pathways, and antioxidant defense systems

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Among them, the protein serine kinase activity demonstrated the highest fold enrichment value at 10.34, indicating a particularly strong overrepresentation in the analyzed dataset (Table S11)