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Therefore, GSTP1 may be involved in complex processes mediated by multiple factors and multiple signals

Oxidative stress worsens mitochondrial damage The elevated production of ROS has been shown to induce depolarization of the mitochondrial membrane potential (m) and the subsequent opening of the mitochondrial permeability transition pore (mPTP) [76, 77]

Lappin MR, Jensen WA, Jensen TD, Basaraba RJ, Brown CA, Radecki SV and Hawley JR (2005)

This activation triggers the mobilization of Glut1 transporters from the cellular cytoplasm to the plasma membrane, leading to an elevation in glucose uptake and a consequent boost in glycolytic activity (20)