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10.1002/ptr.8397 Phytother Res

Abd Elkader AM, Labib S, Taha TF, et al

(9, 10, 11) Furthermore, by damaging the intestinal barrier, ibuprofen allows for the transfer of inflammatory bacteria from the intestine to the liver, causing liver inflammation and promoting the development of nonalcoholic fatty liver disease

The best-known function of the cytochrome P450 enzymes is metabolism of drugs followed by the breakdown of toxic compounds including metabolic byproducts such as bilirubin which can lead to harmful results if not deactivated at a normal rate 2