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This process typically ramps up after 16 to 24 hours of fasting, though it begins on a smaller scale much earlier

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Methods Mice All work was performed as approved by the Institutional Animal Care and Use Committee (IACUC) at Washington University in facilities that meet federal, state and local guidelines for laboratory animal care and are accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care

Furthermore, anti-proteases (i.e., secretory leukocyte protease inhibitor , SLPI) are important for proteolytic inhibition and host defense 673