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Higher doses are subject to the regulations for Therapeutic Use Exemptions (TUE)

This decline accelerates during perimenopause and continues after menopause, when the ovaries significantly reduce or cease hormone production

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To test this, we intraperitoneally administered a single dose of 50 mg/kg STM2457 in DMSO 59 to pregnant E14.5 Ube3C f/f mother mated to Ube3C f/f male