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The peptide space is moving fast, and some of these compounds may prove genuinely valuable for human longevity

It is thought that soluble RAGE acts as a decoy receptor and is protective against the accumulation of amyloid-beta.[ref][ref] One example of how soluble RAGE acts to decrease AGEs can be found in osteoarthritis

Most mutations (including the p.Gly376Asp) promote cytoplasmic mislocalization [20] and formation of toxic protein aggregates [21], coupled to a depletion TDP-43 in the nucleus that causes a loss of the nuclear function of the protein [22]

This imbalance disallows reactive intermediate detoxification by the cell biological systems