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Evaluation of the efficacy of transfer energy capacitive and resistive therapy in patients with knee osteoarthritis. Turkish Journal of Medical Sciences 54.6 (2024): 1302-1309

This transcriptional suppression of inflammatory programs creates a cellular environment favoring repair over continued immune activation, while GHK-Cu's antioxidant propertiesincluding blocking formation of reactive oxygen species, detoxifying lipid peroxidation products such as acrolein, and preventing tissue-damaging free iron releaseprotect regenerating tissues from oxidative damage that can perpetuate inflammatory cycles

Free GHK and the chelated form behave differently at the cellular level, which is one reason researchers specifically study the copper complex rather than the raw tripeptide alone