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Adult neurogenesis transiently generates oxidative stress

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However, studies have increasingly illustrated the important role of HIF in mitochondrial functions, biogenesis, turnover, and redox homeostasis

Studies in Ewings sarcoma cells treated with figitumumab, an IGF-IR antagonist, revealed that this antibody functioned as an IGF-1R-biased agonist through -arrestin1 recruitment to the receptor, enhancing IGF-IR ubiquination and provoking Erk phosphorylation in the absence of Akt activation (92)