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This interaction activates -secretase-mediated proteolytic cleavage of the Notch intracellular domain, which ultimately targets Hes1 and inhibits MUC5AC transcription

To assess the DHT adoption rate in rare disease clinical trials, we conducted a targeted search on ClinicalTrials.gov for all interventional trials related to the ten selected rare diseases, starting from 2017the first year in which more than ten DHT-enabled trials appeared in our dataset

Studies on heat-acclimated vs

doi: 10.3390/ijms22041599 [DOI] [PMC free article] [PubMed] [Google Scholar] 53.Ge Y, Dou T, Nguyen TU, Yadav GP, Wensel TG, Jiang J, et al