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Lip-1 exerts its effects by disrupting iron ion metabolism, mitigating lipid peroxidation-induced cellular damage, and demonstrating neuroprotective properties in cellular models ( -Tocopherol, also known as vitamin E, is a potent natural antioxidant that also functions as a ferroptosis inhibitor, effectively attenuating cellular lipid peroxidation and inhibiting ferroptosis ( Despite their potent anti-ferroptotic effects, these inhibitors face significant challenges in clinical translation, primarily due to pharmacokinetic and physicochemical limitations

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Diabetic neuropathy involves ongoing metabolic insult combined with microvascular damage, and the fact that Cerebrolysin improved nerve fiber parameters in this challenging context suggests robust neurotrophic effects

The Role of OATPs in the Uptake of HMCDs This assertion for the involvement of OATPs is reasonable as hypoxia triggers the activation of HIF1-alpha (HIF1), which promotes OATP expression (70)