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The requirement of a protein pre- or post-organ and -animal development is an important distinction that is not always considered in studies involving tissue-specific knockout mouse models but potentially requires additional investigation

PMID 25576821

In contrast, the safety profile of MeCbl in clinical use has been well proven, and therefore MeCbl can be expected to be repurposed as a therapeutic drug against GSDME-mediated liver failure, and possibly other organ damages