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The found: "The present observations suggest that dysregulation of miR-9 and miR-599 chronologically precedes CHF, suggesting that these miRNA warrant further investigation as putative initiating factors for CHF, while others were found only at the time of CHF (miR-181c and miR-495), which denotes a role in initiation, progression or consequence of CHF

In short, in skeletal muscle, the reaction of BCAA to BCKA yields glutamate which then combines with pyruvate to generate alanine [86]