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Mutations of somatic mtDNA control region (CR) increase with age in postmitotic tissues including the brain, and the level of mtDNA mutations is significantly elevated in the brains of AD patients

Moreover, it markedly prolonged the inhibition of PFC neurons following electrical stimulation of the ventral tegmental area, which could be prevented using a 5-HT 2A antagonist (Godbout et al., 1991)

Importantly, response seems more closely tied to biology (inflammation, obesity) than to the MTHFR genotype alone

In total, 59% were admitted to HH directly from the emergency department (ED), 36% from an inpatient floor, and 5% directly from home