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Title: SARC031: A Phase 2 Trial of the MEK Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Combination with the mTOR Inhibitor Sirolimus for Patients with Unresectable or Metastatic Malignant Peripheral Nerve Sheath Tumors Status: Recruiting For more information about this trial, contact: AeRang Kim, M.D., Ph.D

21 PanaroB

Whether this increases melanoma risk in healthy individuals without pre-existing melanocytic pathology is uncertain, but the concern is biologically plausible and not merely theoretical