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JAMA , 280, 981988

However, a critical gap remains: most current studies focuses on the mechanisms of single herbs or monomer components, while the synergistic effects arising from the complex interplay of components within a formulagoverned by the principles of sovereign, minister, assistant, and messenger are poorly understood

Avalos I, Chung CP, Oeser A, Milne GL, Morrow JD, Gebretsadik T, Shintani A, Yu C, Stein CM: Oxidative stress in systemic lupus erythematosus: relationship to disease activity and symptoms