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For people with confirmed B12 deficiency, this is the gold-standard route

A regular 12-ounce beer typically holds about 5% alcohol by volume (ABV)

Venography in the superior sagittal sinus and in the right jugular external vein reveals bypassing of the termination of the superior sagittal sinus with collaterals presentation centrally and peripherally

And its not because of any magic its because these are natural substances that our bodies make and are familiar with, so thats what gives them this incredible safety profile. The FDA, however, has publicly stated that there is not enough evidence from human clinical trials on the safety or efficacy of these drugs