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Nitrous oxide exposure , whether recreational or occupational, is an additional risk factor as it can cause functional B12 deficiency and neurological injury

Understanding this can help patients appreciate the complexities of their healing journey

Studies in mice have shown that a high concentration of IgG2a is indicative of a Th1 response, while IgG1 presence suggests a Th2 response (60)

arguments against the use of oral cobalamin Oral treatment may be considered in certain situationsfor example, in mild or subclinical deficiency with no clinical features and when absorption and compliance are definitely not a problem