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Abbreviations AKT: Protein kinase B BMI: Body mass index CFA: Cross-sectional fiber area Cox-2: Cytochrome c oxidase subunit II CPTI- II: Carnitine palmityl transferase I and II FOXO: Forkhead box O transcription factor family FOXO3a: Forkhead box O transcription factor 3a GI: Gastrointestinal GM: Gastrocnemius muscle HE: Hematoxylin and eosin HMB: -Hydroxy--methylbutyrate IGF1: Insulin like growth factor 1 IL-1: Interleukin-1 IL-6: Interleukin-6 LC: L-carnitine MaFbx: Muscle atrophy F-box protein MAPK: Mitogen-activated protein kinase mTOR: Mammalian target of rapamycin MuRF1: Muscle RING-type E3 ubiquitin ligase 1 NF-B: Nuclear factor NF-kappa-B PIF: Proteolysis-inducing factor TGF: Transforming growth factor beta TNF-: Tumor Necrosis Factor TWEAK: TNF-like weak inducer of apoptosis References Siegel RL, Miller KD, Jemal A

It also has a certain effect on autoimmune diseases such as RA, bronchial asthma, multiple sclerosis and systemic lupus erythematosus (34)

Hsu PJ, Wang HD, Tseng YC, Pan SW, Sampurna BP, Jong YJ, Yuh CH

Experimental Dermatology, 16, 936-945