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The effects of NTZ were compared to those of the standard antioxidant, N-acetyl cysteine (NAC), as a well-documented hepatoprotective agent known to inhibit ER stress, and to those of 4-phenyl butyrate (4-PBA), a standard ER stress inhibitor (Soliman et al., 2019)

This categorization didnt constitute a formal regulation

I TNG S DNG: -Ngi b nm, sm da, ngi b lo ha da, ngi cn chm sc lm p da

The crystal structure showed that trichostatin A non-covalently binds to the active site of HDACs through the terminal hydroxamic acid group which chelates the Zn 2+ in a bidendate fashion (see Natural Product HDAC Inhibitor in the PDB ) (Sekhavat et al., 2007)