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K + balance and water homeostasis are maintained through Kir4.1 and AQP4 channels, respectively, which are localized at the perivascular endfeet 108,109

The mice were then intraperitoneally injected with either AP probe-net (0.025 or 0.05 mg/kg/d with a volume of 500 l every two days) or dimethyl sulfoxide (DMSO) for the negative control