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Payment for Skin Substitutes In the CY 2023 PFS proposed rule (87 FR 46027 through 46029), we outlined several objectives related to refining skin substitute policies under Medicare, including: (1) ensuring a consistent payment approach for skin substitute products across the physician office and hospital outpatient department settings

To address this issue, nanoparticles can deliver checkpoint inhibitors, such as anti-PD-1 or anti-CTLA-4 antibodies, directly to the tumor microenvironment [75, 76]

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