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Some practitioners combine both approaches

Toure A, Martinez G, Kherraf ZE, et al

Although normally cytosolic, HSPA12B can be released from endothelial cells upon damage, where it promotes the acquisition of a pro-regenerative phenotype in macrophages via TLR4 signaling (Doan et al., 2009) and the PI3KAKTmTOR pathway (Zhou et al., 2020)