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Clinical translational research shows that in a Phase II clinical trial of newly diagnosed high-risk diffuse large B-cell lymphoma (DLBCL) (n=100), oral HDAC inhibitor Tucidinostat (20 mg per dose) in combination with the R-CHOP regimen achieved an 86% complete response rate (91)

doi: 10.3389/fphar.2026.1823729 Received 05 March 2026 Revised 28 April 2026 Accepted 04 May 2026 Published 10 June 2026 Volume 17 - 2026 Edited by Fulvio Celsi, Institute for Maternal and Child Health Burlo Garofolo (IRCCS), Italy Reviewed by Valeria Capaci, University of Trieste, Italy Jarogniew J

Of the 50 patients with a curve, 17 of them had a curve less than 30 degrees with 12 of those with a venous leak