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The mechanism of action of curcumin against tumors is facilitated by three different mechanisms: (i) downregulation of anti-apoptotic proteins which leads to the induction of apoptosis in tumor cells and upregulation of tumor suppressor genes (e.g., p53) (ii) downregulation of MMPs (matrix metalloproteinase), which prevents tumor invasion and (iii) the anti-inflammatory effect which increases its potency against tumors

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As secondary analyses, correlations among GLCM and BSC spectrum-based parameters were evaluated, and immunohistochemistry were used to suggest a structural basis for ultrasound outcomes

Evaluation of the impact of gut microbiota on uremic solute accumulation by a CE-TOFMS-based metabolomics approach